Pharmacological Action Of Furacilin

【Overview】

Nitrofuran, chemical name 5-nitro-2-furan formaldehyde semicarbazone, alias furanxin; furan star; nitrofuran hydrazone; furacillin; Broad-spectrum antibacterial drugs, which are commonly used anti-infection drugs, can interfere with the sugar metabolism process and oxidase system of bacteria to exert antibacterial or bactericidal effects. They mainly interfere with the early stage of bacterial sugar metabolism, leading to bacterial metabolic disorders and death. It is broad and has antibacterial effect on a variety of Gram-positive and negative bacteria. It can prevent and treat common bacterial infection diseases such as gastroenteritis, cholera and coccidiosis in animals. It has been widely used as a feed additive. It is widely used in the treatment of intestinal bacterial infection and other diseases in aquaculture.

【Physical and chemical properties】

Lemon yellow fine crystalline powder, odorless, bitter taste. Sensitive to light, the color gradually turns dark yellow in sunlight. Very slightly soluble in water, slightly soluble in ethanol, easily soluble in polar organic solvents, the color gradually turns dark brown when dissolved in alkaline solution, and the pH of saturated aqueous solution is 5.5-7.5. Melting point 236-240°C.

【Pharmacological action】

Furazone can interfere with the sugar metabolism process and oxidase system of bacteria to play a bacteriostatic or bactericidal effect. It mainly interferes with the early stage of bacterial sugar metabolism, leading to bacterial metabolic disorders and death. It has a wide antibacterial spectrum, has antibacterial effects on a variety of Gram-positive and negative bacteria, and has an effect on anaerobic bacteria. It is ineffective against fungi and molds, but it is still quite effective against bacterial infections caused by molds. The bactericidal concentration for sensitive bacteria is 13-20μg/mL, and the bacteriostatic concentration is 5-10μg/mL.

【Indications】

Furazone is used externally for the treatment of wounds, burns, suppurative dermatitis, otitis media, dacryocystitis, vaginitis, bladder irrigation, bedsores, etc. Rot skin disease (printing disease), bacterial gill rot disease, red skin disease (hemorrhagic putrefaction), bacterial infectious vertical scale disease, fin rot and tail disease, skin inflammation and congestion, chickenpox disease, cave disease, whitehead white Mouth disease.

【Application】

1. For the treatment and prevention of human diseases, such as: for the treatment of chronic myelitis, cervical erosion, adult omphalitis, senile aspiration pneumonia and so on.

2. As a feed additive, it is widely used in livestock, poultry, bees and aquaculture.

3. It can treat and prevent gastrointestinal inflammation, coccidiosis, poultry cholera, etc.

4. Furacilin is mainly used in local treatment. Its antibacterial activity exists in a non-ionic structure and is not affected by the pH value of the body fluid. Except that it is ineffective against Pseudomonas aeruginosa, it is enough to kill most of the common pathogenic bacteria that cause wound infection, and rarely develops drug resistance. . Soaking the urinary catheter with nitrofurazone can effectively prevent the occurrence of urinary tract infection caused by indwelling catheter, and high temperature and high pressure disinfection does not affect the antibacterial activity and content of nitrofurazone on the urinary catheter. Topical application of nitrofurazone can treat and prevent wound infections, such as pyoderma, Ⅱ and Ⅲ degree burns, skin grafts and donor site infections. Treating acute bacillary dysentery with nitrofurazone solution enema, the relief of abdominal pain is not obvious, but the effect of antidiarrheal is remarkable.

【Dosage】

Topical application: 0.01% to 0.02% solution on the wound surface for washing or wet compress. 0.2% ~ 1% ointment coating. Compound nitrofurazone nasal drops contains 0.02% of this product and 1% of ephedrine hydrochloride, and is used for nasal drops. Its 0.001% ~ 0.005% solution can be used for gargling.

Just contact us via email: info@haozbio.com for any questions.